abstract：:The Polymerase Associated Factor 1 complex (Paf1C) is a multifunctional regulator of eukaryotic gene expression important for the coordination of transcription with chromatin modification and post-transcriptional processes. In this study, we investigated the extent to which the functions of Paf1C combine to regulate t...

journal_title：Genetics

authors： Ellison MA,Lederer AR,Warner MH,Mavrich TN,Raupach EA,Heisler LE,Nislow C,Lee MT,Arndt KM

更新日期：2019-07-01 00:00:00

abstract：:Neurospora crassa is an established reference organism to investigate carotene biosynthesis and light regulation. However, there is little evidence of its capacity to produce secondary metabolites. Here, we report the role of the fungal-specific regulatory velvet complexes in development and secondary metabolism (SM) ...

journal_title：Genetics

authors： Bayram ÖS,Dettmann A,Karahoda B,Moloney NM,Ormsby T,McGowan J,Cea-Sánchez S,Miralles-Durán A,Brancini GTP,Luque EM,Fitzpatrick DA,Cánovas D,Corrochano LM,Doyle S,Selker EU,Seiler S,Bayram Ö

更新日期：2019-07-01 00:00:00

abstract：:Transvection is the phenomenon where a transcriptional enhancer activates a promoter located on the homologous chromosome. It has been amply documented in Drosophila where homologs are closely paired in most, if not all, somatic nuclei, but it has been known to rarely occur in mammals as well. We have taken advantage ...

journal_title：Genetics

authors： Piwko P,Vitsaki I,Livadaras I,Delidakis C

更新日期：2019-06-01 00:00:00

abstract：:There is an increasing awareness that selection affecting linked neutral sites strongly influences on how diversity is distributed across the genome. In particular, linked selection is likely involved in the formation of heterogenous landscapes of genetic diversity, including genomic regions with locally reduced effec...

journal_title：Genetics

authors： Rettelbach A,Nater A,Ellegren H

更新日期：2019-05-01 00:00:00

abstract：:A long-standing prediction in evolutionary biology is that organisms experience a so-called "cost of complexity" manifested as a decreasing rate of adaptation in populations as organisms or selective environments become increasingly complex. This theory assumes the ubiquity of antagonistic pleiotropy, or trade-offs in...

journal_title：Genetics

authors： Sackman AM,Rokyta DR

更新日期：2019-05-01 00:00:00

abstract：:Sir2 is a highly conserved NAD+-dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, Saccharomyces cerevisiae Within the yeast rDNA locus, Sir2 is required for efficient cohesin recruitment and maintaining the stability of the tandem a...

journal_title：Genetics

authors： Fine RD,Maqani N,Li M,Franck E,Smith JS

更新日期：2019-05-01 00:00:00

abstract：:Selection of suppressor mutations that correct growth defects caused by substitutions in an RNA or protein can reveal functionally important molecular structures and interactions in living cells. This approach is particularly useful for the study of complex biological pathways involving many macromolecules, such as pr...

journal_title：Genetics

authors： Brow DA

更新日期：2019-05-01 00:00:00

abstract：:To understand gene function, the cre/loxP conditional system is the most powerful available for temporal and spatial control of expression in mouse. However, the research community requires more cre recombinase expressing transgenic mouse strains (cre-drivers) that restrict expression to specific cell types. To addres...

journal_title：Genetics

authors： Korecki AJ,Hickmott JW,Lam SL,Dreolini L,Mathelier A,Baker O,Kuehne C,Bonaguro RJ,Smith J,Tan CV,Zhou M,Goldowitz D,Deussing JM,Stewart AF,Wasserman WW,Holt RA,Simpson EM

更新日期：2019-04-01 00:00:00

abstract：:We leverage two complementary Drosophila melanogaster mapping panels to genetically dissect starvation resistance-an important fitness trait. Using >1600 genotypes from the multiparental Drosophila Synthetic Population Resource (DSPR), we map numerous starvation stress QTL that collectively explain a substantial fract...

journal_title：Genetics

authors： Everman ER,McNeil CL,Hackett JL,Bain CL,Macdonald SJ

更新日期：2019-04-01 00:00:00

abstract：:Differences in mating behaviors evolve early during speciation, eventually contributing to reproductive barriers between species. Knowledge of the genetic and genomic basis of these behaviors is therefore integral to a causal understanding of speciation. Acoustic behaviors are often part of the mating ritual in animal...

journal_title：Genetics

authors： Xu M,Shaw KL

更新日期：2019-03-01 00:00:00

abstract：:Hybridization between related species results in the formation of an allopolyploid with multiple subgenomes. These subgenomes will each contain complete, yet evolutionarily divergent, sets of genes. Like a diploid hybrid, allopolyploids will have two versions, or homeoalleles, for every gene. Partial functional redund...

journal_title：Genetics

authors： Santantonio N,Jannink JL,Sorrells M

更新日期：2019-03-01 00:00:00

abstract：:To reveal phenotypic and functional genomic patterns of mitonuclear adaptation, a laboratory adaptation study with Caenorhabditis elegans nematodes was conducted in which independently evolving lines were initiated from a low-fitness mitochondrial electron transport chain (ETC) mutant, gas-1 Following 60 generations o...

journal_title：Genetics

authors： Wernick RI,Christy SF,Howe DK,Sullins JA,Ramirez JF,Sare M,Penley MJ,Morran LT,Denver DR,Estes S

更新日期：2019-03-01 00:00:00

abstract：:In most species, size homeostasis appears to be exerted in late G1 phase as cells commit to division, called Start in yeast and the Restriction Point in metazoans. This size threshold couples cell growth to division, and, thereby, establishes long-term size homeostasis. Our former investigations have shown that hundre...

journal_title：Genetics

authors： Chaillot J,Tebbji F,Mallick J,Sellam A

更新日期：2019-02-01 00:00:00

abstract：:During meiotic prophase I, sister chromatid cohesion is established in a way that supports the assembly of the synaptonemal complex (SC). The SC connects homologous chromosomes, directing meiotic recombination to create crossovers. In this paper, we identify two proteins that cooperate to import and load meiotic cohes...

journal_title：Genetics

authors： Bowman R,Balukof N,Ford T,Smolikove S

更新日期：2019-02-01 00:00:00

abstract：:Heterochromatin protein 1a (HP1a) is a highly conserved and versatile epigenetic factor that can both silence and activate transcription. However, the function of HP1a in development has been underinvestigated. Here, we report the role of maternal HP1a in producing maternal transcripts that drive early Drosophila embr...

journal_title：Genetics

authors： Park AR,Liu N,Neuenkirchen N,Guo Q,Lin H

更新日期：2019-01-01 00:00:00

abstract：:Population structure leads to systematic patterns in measures of mean relatedness between individuals in large genomic data sets, which are often discovered and visualized using dimension reduction techniques such as principal component analysis (PCA). Mean relatedness is an average of the relationships across locus-s...

journal_title：Genetics

authors： Li H,Ralph P

更新日期：2019-01-01 00:00:00

abstract：:The pathogenic life cycle of the rice blast fungus Magnaporthe oryzae involves a series of morphogenetic changes, essential for its ability to cause disease. The smo mutation was identified > 25 years ago, and affects the shape and development of diverse cell types in M. oryzae, including conidia, appressoria, and asc...

journal_title：Genetics

authors： Kershaw MJ,Basiewicz M,Soanes DM,Yan X,Ryder LS,Csukai M,Oses-Ruiz M,Valent B,Talbot NJ

更新日期：2019-01-01 00:00:00

abstract：:The human pathogen Candida albicans is considered an obligate commensal of animals, yet it is occasionally isolated from trees, shrubs, and grass. We generated genome sequence data for three strains of C. albicans that we isolated from oak trees in an ancient wood pasture, and compared these to the genomes of over 200...

journal_title：Genetics

authors： Bensasson D,Dicks J,Ludwig JM,Bond CJ,Elliston A,Roberts IN,James SA

更新日期：2019-01-01 00:00:00

abstract：:Mitotic cell divisions increase cell number while faithfully distributing the replicated genome at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell division. Nearly all of the genes that regulate cell division in C. elegans are conserved across metazoan species, including humans...

journal_title：Genetics

authors： Pintard L,Bowerman B

更新日期：2019-01-01 00:00:00

abstract：:Hybrid sterility is a common form of reproductive isolation between nascent species. Although hybrid sterility is routinely documented and genetically dissected in speciation studies, its developmental basis is rarely examined, especially in generations beyond the F1 generation. To identify phenotypic and genetic dete...

journal_title：Genetics

authors： Schwahn DJ,Wang RJ,White MA,Payseur BA

更新日期：2018-12-01 00:00:00

abstract：:Cells expend a large amount of energy to maintain their DNA sequence. DNA repair pathways, cell cycle checkpoint activation, proofreading polymerases, and chromatin structure are ways in which the cell minimizes changes to the genome. During replication, the DNA-damage tolerance pathway allows the replication forks to...

journal_title：Genetics

authors： Thurston AK,Radebaugh CA,Almeida AR,Argueso JL,Stargell LA

更新日期：2018-12-01 00:00:00

abstract：:Dealing with physiological stress is a necessity for all organisms, and the pathways charged with this task are highly conserved in Metazoa . Accumulating evidence highlights cell-nonautonomous activation as an important mode of integrating stress responses at the organism level. Work in Caenorhabditis elegans highlig...

journal_title：Genetics

authors： Liu L,Ruediger C,Shapira M

更新日期：2018-12-01 00:00:00

abstract：:Parentage analysis is an important method that is used widely in zoological and ecological studies. Current mathematical models of parentage analyses usually assume that a population has a uniform genetic structure and that mating is panmictic. In a natural population, the geographic or social structure of a populatio...

journal_title：Genetics

authors： Huang K,Mi R,Dunn DW,Wang T,Li B

更新日期：2018-12-01 00:00:00

abstract：:Detecting and quantifying the differences in individual genomes (i.e., genotyping), plays a fundamental role in most modern bioinformatics pipelines. Many scientists now use reduced representation next-generation sequencing (NGS) approaches for genotyping. Genotyping diploid individuals using NGS is a well-studied fie...

journal_title：Genetics

authors： Gerard D,Ferrão LFV,Garcia AAF,Stephens M

更新日期：2018-11-01 00:00:00

abstract：:The Genetics Society of America's (GSA) Edward Novitski Prize is awarded to researchers who have solved challenging problems in genetics through experiments that demonstrate exceptional creativity and ingenuity. Job Dekker of the University of Massachusetts Medical School has been selected for the 2018 award in recogn...

journal_title：Genetics

authors： Haloupek N

更新日期：2018-11-01 00:00:00

abstract：:The genetic etiology of many complex diseases is highly heterogeneous. A complex disease can be caused by multiple mutations within the same gene or mutations in multiple genes at various genomic loci. Although these disease-susceptibility mutations can be collectively common in the population, they are often individu...

journal_title：Genetics

authors： Li M,He Z,Tong X,Witte JS,Lu Q

更新日期：2018-10-01 00:00:00

abstract：:OrthoList, a compendium of Caenorhabditis elegans genes with human orthologs compiled in 2011 by a meta-analysis of four orthology-prediction methods, has been a popular tool for identifying conserved genes for research into biological and disease mechanisms. However, the efficacy of orthology prediction depends on th...

journal_title：Genetics

authors： Kim W,Underwood RS,Greenwald I,Shaye DD

更新日期：2018-10-01 00:00:00

abstract：:Boundaries (insulators) in the Drosophila bithorax complex (BX-C) delimit autonomous regulatory domains that orchestrate the parasegment (PS)-specific expression of the BX-C homeotic genes. The Fab-7 boundary separates the iab-6 and iab-7 regulatory domains, which control Abd-B expression in PS11 and PS12, respectivel...

journal_title：Genetics

authors： Fedotova A,Aoki T,Rossier M,Mishra RK,Clendinen C,Kyrchanova O,Wolle D,Bonchuk A,Maeda RK,Mutero A,Cleard F,Mogila V,Karch F,Georgiev P,Schedl P

更新日期：2018-10-01 00:00:00

abstract：:The supramolecular striatin-interacting phosphatases and kinases (STRIPAK) complex is conserved from yeast to human, and regulates a variety of key biological processes. In animals, this complex consists of the scaffold protein striatin, the protein phosphatase 2A, and kinases, such as germinal center kinase (GCK) III...

journal_title：Genetics

authors： Radchenko D,Teichert I,Pöggeler S,Kück U

更新日期：2018-09-01 00:00:00

abstract：:Adherence, an important virulence factor, is mediated by the EPA (Epithelial Adhesin) genes in the opportunistic pathogen Candida glabrata Expression of adhesin-encoding genes requires tight regulation to respond to harsh environmental conditions within the host. The majority of EPA genes are localized in subtelomeric...

journal_title：Genetics

authors： López-Fuentes E,Hernández-Hernández G,Castanedo L,Gutiérrez-Escobedo G,Oktaba K,De Las Peñas A,Castaño I

更新日期：2018-09-01 00:00:00

abstract：:Many heterogametic organisms adjust sex chromosome expression to accommodate differences in gene dosage. This requires selective recruitment of regulatory factors to the modulated chromosome. How these factors are localized to a chromosome with requisite accuracy is poorly understood. Drosophila melanogaster males inc...

journal_title：Genetics

authors： Deshpande N,Meller VH

更新日期：2018-08-01 00:00:00

abstract：:Adaptive introgression is common in nature and can be driven by selection acting on multiple, linked genes. We explore the effects of polygenic selection on introgression under the infinitesimal model with linkage. This model assumes that the introgressing block has an effectively infinite number of loci, each with an...

journal_title：Genetics

authors： Sachdeva H,Barton NH

更新日期：2018-08-01 00:00:00

abstract：:Resolving the mechanistic and genetic bases of reproductive barriers between species is essential to understanding the evolutionary forces that shape speciation. Intrinsic hybrid incompatibilities are often treated as fixed between species, yet there can be considerable variation in the strength of reproductive isolat...

journal_title：Genetics

authors： Larson EL,Vanderpool D,Sarver BAJ,Callahan C,Keeble S,Provencio LL,Kessler MD,Stewart V,Nordquist E,Dean MD,Good JM

更新日期：2018-07-01 00:00:00

abstract：:High-throughput sequencing and bioinformatic techniques have enhanced classical genetic analysis and are essential methods for geneticists. Tsukamoto and colleagues use numerous genomic and bioinformatics methods to explore the role of ribonucleoprotein complexes in regulating oocyte meiotic maturation, which is the t...

journal_title：Genetics

authors： Thurtle-Schmidt D,Lo TW

更新日期：2018-07-01 00:00:00

abstract：:Histone chaperones, chromatin remodelers, and histone modifying complexes play a critical role in alleviating the nucleosomal barrier for DNA-dependent processes. Here, we have examined the role of two highly conserved yeast (Saccharomyces cerevisiae) histone chaperones, facilitates chromatin transcription (FACT) and ...

journal_title：Genetics

authors： Pathak R,Singh P,Ananthakrishnan S,Adamczyk S,Schimmel O,Govind CK

更新日期：2018-07-01 00:00:00

abstract：:We study the establishment probabilities of locally adapted mutations using a multi-type branching process framework. We find a surprisingly simple and intuitive analytical approximation for the establishment probabilities in a symmetric two-deme model under the assumption of weak (positive) selection. This is the fir...

journal_title：Genetics

authors： Tomasini M,Peischl S

更新日期：2018-07-01 00:00:00

abstract：:Heterogeneous genetic divergence can accumulate across the genome when populations adapt to different habitats while still exchanging alleles. How long does diversification take and how much of the genome is affected? When divergence occurs in parallel from standing genetic variation, how often are the same haplotypes...

journal_title：Genetics

authors： Bassham S,Catchen J,Lescak E,von Hippel FA,Cresko WA

更新日期：2018-07-01 00:00:00

abstract：:The protein phosphatase calcineurin is central to Ca2+ signaling pathways from yeast to humans. Full activation of calcineurin requires Ca2+ binding to the regulatory subunit CNB, comprised of four Ca2+-binding EF hand domains, and recruitment of Ca2+-calmodulin. Here we report the consequences of disrupting Ca2+ bind...

journal_title：Genetics

authors： Connolly S,Quasi-Woode D,Waldron L,Eberly C,Waters K,Muller EM,Kingsbury TJ

更新日期：2018-07-01 00:00:00

abstract：:Maintenance of cell integrity and cell-to-cell communication are fundamental biological processes. Filamentous fungi, such as Neurospora crassa, depend on communication to locate compatible cells, coordinate cell fusion, and establish a robust hyphal network. Two MAP kinase (MAPK) pathways are essential for communicat...

journal_title：Genetics

authors： Fischer MS,Wu VW,Lee JE,O'Malley RC,Glass NL

更新日期：2018-06-01 00:00:00

abstract：:The heterotrimeric G protein Gq regulates neuronal activity through distinct downstream effector pathways. In addition to the canonical Gq effector phospholipase Cβ, the small GTPase Rho was recently identified as a conserved effector of Gq. To identify additional molecules important for Gq signaling in neurons, we pe...

journal_title：Genetics

authors： Coleman B,Topalidou I,Ailion M

更新日期：2018-06-01 00:00:00